CultureOne
Alfa Laval CultureOne es una gama premium de separadores diseñados para la recolección de células de un solo uso en el procesamiento biofarmacéutico. Con innovaciones comprobadas para un tratamiento cuidadoso del producto y un mayor rendimiento, CultureOne proporciona una eficiencia de separación inigualable para cultivos celulares de alta densidad.
Centrífugas probadas y de primera calidad para mejorar la producción biofarmacéutica de un solo uso
- La recuperación comprobada del producto produce hasta un 99%
- Fácilmente escalable a separadores de acero inoxidable Alfa Laval más grandes
- Entre un 50 y un 80 % menos de agua, energía y agentes de limpieza en comparación con los métodos de recolección basados en filtros, con solo una frac
- Cosecha más rápida en grandes volúmenes y altas densidades celulares
- Diseño compacto y cambio de lote rápido
Con los separadores CultureOne, podrá aprovechar al máximo su producto cosechado. Nuestros separadores ofrecen rendimientos de producto más altos que otras tecnologías de un solo uso, con rendimientos de hasta el 99 %. El separador Hermetic Design CultureOne garantiza un tratamiento suave para reducir la lisis celular y evitar la formación de espuma, lo que resulta en una purificación posterior más sencilla. Con Alfa Laval Spinsert, nuestra pila de discos patentada de un solo uso, podrá configurar y reemplazar fácilmente, lo que garantiza un cambio de lote rápido.
Nuestro rendimiento de separación superior produce un concentrado claro con un contenido de sólidos remanentes muy bajo. Esto minimiza la necesidad de filtración secundaria, lo que reduce en gran medida la huella ecológica.
Los separadores CultureOne son fáciles de operar, como unidades independientes o conectados a un sistema centralizado. La automatización y la conectividad proporcionan una integridad completa de los datos, de conformidad con 21 CFR Parte 11.
Did you know?
With the Alfa Laval CultureOne range, you can scale your single-use bioprocess easily and efficiently. Our bioprocess equipment and automation solutions help you avoid data and time losses. They also meet GMP requirements for your manufacturing facility and ensure system validation, data integrity and product quality. Plus, Alfa Laval experts can support you during commissioning, validation, and qualification for GMP production. Contact us today to learn more.
The CultureOne range
CultureOne™ separators enhance efficiency in single-use bioprocessing, increasing product recovery and streamlining workflows from R&D to production scale.
How this centrifuge enhances cell harvesting in biopharma?
Curious about the CultureOne™ separators? In this short animation, you can explore how these advanced systems support cell harvesting.
CultureOne Primo
- Processing capacity: 240 litres/hour
- Product recovery yield: Up to 99%
CultureOne Maxi
- Processing capacity: 720 litres/hour
- Product recovery yield: Up to 99%
* Capacity figures for fed-batch mammalian cell culture materials. Actual process performance is a function of individual material characteristics.
Main facts about CultureOne™
Improving yields at every scale
The CultureOne separation platform is designed to maximize the potential of every cell culture, delivering unparalleled yields, ensuring product quality with utmost security, and minimizing additional lysis. The range ensures consistent performance throughout the transition from R&D to full-scale production, allowing for seamless scalability.
Developed with the industry to meet the most challenging demands
The CultureOne separation system was developed in close collaboration with leading biopharmaceutical manufacturers. Its unique performance has been verified in a wide range of processes to ensure it can meet ever-changing demands.
Less waste in single-use processing
With CultureOne separators, you can reduce the amount of water, chemicals, and plastic consumables required for single-use biopharma processing by 50 to 80%. The result is lower costs and added sustainability.
Services
Amplía el rendimiento de su equipo
Nuestra red de servicio global especial le proporciona soporte con piezas y conocimiento experto allí donde esté y siempre que lo necesite. Al garantizar un tiempo de operación, una disponibilidad y una optimización mayores, le proporcionamos tranquilidad y maximizamos el retorno de la inversión. Podemos colaborar con usted para integrar nuestros servicios en un acuerdo de servicio de Alfa Laval para que sus operaciones sean predecibles y no le causen preocupaciones.
Are you considering single-use technology for biopharmaceutical manufacturing?
Why switch to single-use processing?
A single-use separation system secures patient safety by eliminating the risk of cross-contamination between batches. Single-use processing also enables a reduced footprint and increased flexibility, with no need for sterilization: empowering manufacturers to bring new treatments to market faster than ever before.
A better harvest with centrifugal separation
Many single-use harvesting systems cannot efficiently separate high-density cell cultures. The resulting product loss dramatically impacts the productivity and profitability of biopharmaceutical operations. CultureOne overcomes this problem by combining high-efficiency centrifugal separation with secure and convenient single-use processing.
Safety and quality with Spinsert™
CultureOne's performance is based on the Spinsert, a patented single-use disposable bowl and disc stack assembly – fully sterilized and ready for processing. Easy to set up and replace, it ensures fast batch changeover. It is made from recyclable polymers suited for biopharma processing.
Proven and published performance in biopharmaceutical processing
BioProcess International published a study detailing the performance of CultureOne Primo. Made in collaboration with Genentech, the study shows that the single-use centrifuge gives a recovery yield rate of up to 99% in cell harvesting and single-use bioprocessing.
Test, validate, and scale up your next separation solution
Whether upgrading your production line or running a proof of concept, Alfa Laval helps you choose the right separator solution with confidence. Simply get in touch to arrange a consultation and trial at one of our test centres, or to rent a unit for onsite testing.
